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    Browsing BEAR Day 2020 by Subject "School of Medicine"

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        Activation of Lanthionine Synthetase C-like 2 Protein (LANCL2) Attenuates Spinal Neuroinflammation and Neuropathic Pain in Rats

        Han-Rong Weng; David Christy
        The LANCL2 protein represents a novel target for the alleviation of neuropathic pain through administration of its natural ligand abscisic acid.
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        Calcitriol and Its Eeffects on Staphylococcal Enterotoxin B (SEB)-Induced Inflammation in Mice Spleen Cells

        Robert J. McKallip; Anish Sutaria; Olga N. Uchakina
        The active form of vitamin D, Calcitriol, upregulates different anti-inflammatory pathway. In this study we investigated effect of Calcitriol on Staphylococcal enterotoxin B (SEB)-induced inflammation in spleen cells.
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        Efficacy of C-Fos Inhibition In Patch Compartment Upon Habitual Methamphetamine Administration

        Ashley Horner; Troy Kendrick; Bhuvaneshwari Muchandi
        The study evaluates whether deactivating C-Fos neuronal expression in patch compartment decreases habit formation in methamphetamine administration
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        GLP-1 Receptor Agonists Improve Cerebrovascular Integrity and Vascular Cognitive Impairment and Dementia via Recovery of Brain Pericytes Functions in Diabetic Mice

        Mohammed Abdelsaid; Joseph Bailey; Amy Barrett
        Diabetic animals treated with GLP-1R agonists demonstrate an improvement in memory and learning through recovery of brain pericyte activity.
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        Linkages of the Epstein-Barr Virus in Developing Nations

        Gretchen Bentz; Peter Garcia
        This project aims to examine and analyze the effects of Epstein-Barr Virus in developing nations.
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        Methamphetamine Induced Immune Dysregulation

        Peter Uchakin; Sydney Andrzejak
        In this study we aim to analyze how methamphetamine modulates Th1-Th2-Treg-Th17-Th22-Th9 (ThX) pathways in CTX-TNA2 astrocyte cell line.
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        Proximal Tubular Hypertrophy Enhances Basolateral Uptake of Mercury

        Christy Bridges; Kayla Matta; Delon Barfuss; Lucy Joshee
        Animals were used to test the effects of mercury in control and hypertrophied kidneys
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        Reduction of Angiotensin II Induced Hypertension and Cardiac Fibrosis with GLP-1 Receptor Agonist and DPP-4 Inhibitor via Decreasing NADPH Oxidase Expression

        Zhi-Qing Zhao; Ning-Ping Wang; Trenton Banks
        This study entails focus on Ang II infused cardiac fibrosis, NADPH oxidases role in the inflammation pathway, and possible treatment options in GLP-1 agonists and DPP-4 inhibitors
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        Role of Sumoylation in the EBV Life-Cycle

        Gretchen Bentz; Angela Lowrey; Abby Harrod; Shakti Biswas; Peter Garcia; Falisha Hira; Shruti Jha; Alex Barnhill; Ananya Shah; Holden Lee; et al.
        We examined the effects of a novel, SAE small molecule inhibitor, ML-792, on protein sumoylation in multiple B cell lines infected with EBV.
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        Targeting Chronic Myelogenous Leukemia with Imatinib and Glycyrrhizic Acid Combination Therapy

        Robert J. McKallip; Adir Mohaban; Olga N. Uchakina
        Examining the efficacy of an imatinib and glycyrrhizic acid combination treatment on chronic myelogenous leukemia cell lines. As well as examining the mechanism of action of glycyrrhizic acid.
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        Understanding the Nature of Glycyrrhizic Acid in Breast Cancer Treatment

        Robert McKallip; Jessica Hall; Olga Uchakina
        Modulation of HA metabolisms, both production and cleavage, by BC provides for a protective environment preventing the cells from therapy induced cell death or apoptosis. We suggest that inhibition of HA degradation by HYAL may be key in limiting the migration and progression of breast cancer.
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